Dr. John Tolbert and co-authors Tyler French, Andrew Kitson, Chiebuka Okpara, Diana Hammerstone and our collaborators Prof. Tomas Gonzalez-Fernandez in Lehigh BIOE and Santiago Lazarte, Tomas Babuska, and Prof. Brandon Krick at FAMU-FSU College of Engineering published a paper titled, “Solvent-cast 3D printing with molecular weight polymer blends to decouple effects of scaffold architecture and mechanical properties on mesenchymal stromal cell fate” in the Journal of Biomedical Materials Part A! We printed with inks containing different ratios of high and low molecular weight polymer to modify scaffold stiffness without affecting scaffold architecture or surface chemistry. We found that low stiffness scaffolds supported stable human mesenchymal stromal cell (hMSC) chondrogenesis while high stiffness promoted hypertrophy under chondrogenic conditions. Check it out to learn more about our platform and how you can independently tune physical and biochemical properties!
the chow lab 